Preheat and prep. Heat your oven to 375°F (190°C).
Lightly grease a 9x13-inch baking dish with olive oil spray or a thin smear of butter.
Cook the pasta. Boil the macaroni in salted water until just shy of al dente, 1–2 minutes less than the package says. Drain and set aside. Slightly undercooked pasta finishes in the oven without turning mushy.
Blend the sauce. In a blender or food processor, add cottage cheese, Greek yogurt, 1 cup shredded cheddar, Parmesan, 1/2 cup milk, Dijon, garlic powder, onion powder, smoked paprika, 1/2 teaspoon salt, and 1/4 teaspoon pepper.
Blend until completely smooth. If it’s too thick, blend in more milk, a splash at a time.
Taste and adjust. Dip a spoon in and adjust salt, pepper, or mustard. The sauce should taste slightly salty and cheesy; the pasta will mellow it out.
Combine. In a large bowl, toss the drained pasta with the blended sauce until every piece is coated.
Assemble. Pour into the prepared baking dish.
Sprinkle the remaining 1/2 cup cheddar on top. If using, add a light layer of panko for crunch.
Bake. Bake for 18–22 minutes, until the edges bubble and the top lightly browns. For extra color, broil for 1–2 minutes at the end, watching closely.
Rest and serve. Let it sit for 5–10 minutes so the sauce sets slightly.
Scoop and enjoy now, or portion for meal prep.