Preheat and prep: Heat your oven to 375°F (190°C). Grease a 9x13-inch baking dish.
Sauté aromatics: In a large skillet over medium heat, melt the butter.
Add the onion and cook 3–4 minutes until softened. Stir in the garlic and cook 30 seconds until fragrant.
Soften the veggies: Add the mixed vegetables to the skillet. If using frozen, cook 3–5 minutes until just thawed and bright.
If using fresh, cook until crisp-tender. Remove from heat.
Mix the sauce: In a large bowl, whisk together the cream of chicken soup, sour cream, milk, ranch seasoning, black pepper, smoked paprika, and red pepper flakes.
Combine: Fold the cooked chicken, sautéed vegetables, and 1 cup shredded cheddar into the sauce. Taste and adjust salt if needed.
Assemble: Spread the mixture evenly in the baking dish.
Top it: In a small bowl, combine your crunchy topping with the melted butter.
Sprinkle evenly over the casserole. Add an extra handful of cheese on top if you like a gooey finish.
Bake: Place the casserole in the oven and bake 25–30 minutes, until bubbling at the edges and golden on top.
Rest and garnish: Let it rest 5–10 minutes to set. Sprinkle with fresh parsley or chives before serving.